Syndecan 4 Signaling and Intervertebral Disc Degeneration
نویسندگان
چکیده
منابع مشابه
incidence of microscopic lumbar intervertebral disc calcification and its correlation to endplate degeneration type and disc histopathologic angiogensis
چکیده ندارد.
15 صفحه اولIntervertebral Disc Dynamics and Degeneration
Degenerative disc disease is a serious health problem worldwide, whose etiological basis – mechanical stimulus, biochemical changes, or natural aging – is poorly understood. While the disc’s known function is that of dynamic shock absorber, its dynamic response has not been fully characterized throughout the disc health spectrum (from healthy to degenerate). Therefore, this study aimed to corre...
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The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body. It is believed to be important clinically because there is an association of disc degeneration with back pain. Current treatments are predomina...
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cluding cytokines, growth factors, enzymes, and enzyme inhibitors, in a paracrine or/and autocrine fashion.1,2 Anabolic regulators include polypeptide growth factors, such as insulin-like growth factor (IGF), transforming growth factor-β (TGF-β), and the bone morphogenetic proteins (BMPs).1–4 Other small molecules, such as the synthetic peptide of link protein, have also been reported to be reg...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2014
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2014.07.001